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自体结膜游离移植(FCG)翼状胬肉切除术与术后锶90(90Sr)β射线照射的前瞻性研究。

Pterygium excision with free conjunctival autograft (FCG) versus postoperative strontium 90 (90Sr) beta-irradiation. A prospective study.

作者信息

de Keizer R J

机构信息

Department of Ophthalmology, University Hospital, Leiden, The Netherlands.

出版信息

Int Ophthalmol. 1997;21(6):335-41. doi: 10.1023/a:1006070503345.

DOI:10.1023/a:1006070503345
PMID:9869343
Abstract

In a prospective study the results of a pterygium excision in 54 patients (57 eyes) who underwent a superficial free conjunctival autograft (FCG) were compared to those of patients who were treated with postoperative 90Sr-irradiation. In 51 cases the minimum follow-up was six months, the maximum follow-up seven years. We divided the study up into a randomized part and an open part. In the randomized part, surgery of a primary pterygium was performed in 25 eyes, of which 16 were treated with a FCG and compared with 9 eyes with primary pterygium surgery and postoperative 90Sr beta-irradiation. In the same period 16 eyes were treated because of a recurrent pterygium: 8 with FCG and 8 with 90Sr-irradiation. In the open part of the study 16 eyes with primary pterygium were successively treated with FCG alone. The results showed in the randomized, as well as in the open study on primary surgery with a minimum follow-up of six month, one recurrence in each of the FCG-groups (2 out of 31 eyes = 6.4%), and no recurrences in the 90Sr-group (0%). In the randomized group of patients treated for a recurrent pterygium one recurrence developed in the FCG group (1 out of 8 eyes = 12.5%) and one in the 90Sr-group (1 out of 7 = 14.6%). Analysis of other clinical parameters showed that postoperative treatment with corticosteroids, nonsteroidal anti-inflammatory drugs, and artificial tears was necessary for a longer period in the FCG group than in the 90Sr-group.

摘要

在一项前瞻性研究中,对54例患者(57只眼)行翼状胬肉切除联合浅层游离结膜自体移植术(FCG)的结果与术后接受90Sr照射患者的结果进行了比较。51例患者的最短随访时间为6个月,最长随访时间为7年。我们将该研究分为随机分组部分和开放部分。在随机分组部分,对25只眼的原发性翼状胬肉进行手术,其中16只眼接受FCG治疗,并与9只接受原发性翼状胬肉手术及术后90Srβ射线照射的眼进行比较。同期,对16只因复发性翼状胬肉而接受治疗的眼进行了研究:8只眼接受FCG治疗,8只眼接受90Sr照射。在该研究的开放部分,16只原发性翼状胬肉眼先后单独接受FCG治疗。结果显示,在随机分组部分以及开放部分的原发性手术研究中,最短随访6个月时,FCG组各有1例复发(31只眼中2例 = 6.4%),90Sr组无复发(0%)。在复发性翼状胬肉治疗的随机分组患者中,FCG组有1例复发(8只眼中1例 = 12.5%),90Sr组有1例复发(7只眼中1例 = 14.6%)。对其他临床参数的分析表明,FCG组术后使用皮质类固醇、非甾体类抗炎药和人工泪液的时间比90Sr组长。

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1
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本文引用的文献

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Late effects of beta radiation on the eye.β射线对眼睛的远期效应。
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Late complications of pterygium treatment.翼状胬肉治疗的晚期并发症。
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Preventable complications of pterygium excision with beta-irradiation.翼状胬肉切除联合β射线照射的可预防并发症
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8
Conjunctival autograft transplantation for advanced and recurrent pterygium.结膜自体移植治疗晚期复发性翼状胬肉。
Ophthalmology. 1985 Nov;92(11):1461-70. doi: 10.1016/s0161-6420(85)33831-9.
9
Results of pterygium excision with Sr 90 irradiation, lamellar keratoplasty and conjunctival flaps.翼状胬肉切除联合锶90照射、板层角膜移植术及结膜瓣手术的结果
Doc Ophthalmol. 1987 Sep-Oct;67(1-2):33-44. doi: 10.1007/BF00142695.
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Mitomycin eye drops as treatment for pterygium.
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