Klein L, Mĕricka P, Straková H, Jebavý L, Nozicková M, Bláha M, Talábová Z, Hosek F
Dept. of Plastic Surgery and Burns Treatment, Teaching Hospital Purkinje Military Medical Academy.
Ann Transplant. 1997;2(1):45-8.
The treatment of two cases of toxic epidermal necrolysis (Lyell's syndrome) is described. Although some features were common for both ones (young men practically of the same age, reaction after using the same drug) the clinical course of illness was very different. Spontaneous epithelisation of partial-thickness lesions and definitive healing under the xenografts in one patient and full-thickness skin-loss on 12% of body surface with severe septic complications requiring application of cultured keratinocytes and/or skin autografting in the other patient were the main differences. The interdisciplinary approach using a burns treatment protocol in non-burned patient including the close co-operation with the tissue bank in preparing different types of biological covers has been applied.
本文描述了两例中毒性表皮坏死松解症（莱尔综合征）的治疗情况。尽管两例患者有一些共同特征（年龄相仿的年轻男性，使用同一种药物后出现反应），但其临床病程却大不相同。主要差异在于，一例患者部分厚度皮损自发上皮化并在异种移植下实现最终愈合，而另一例患者体表12%出现全层皮肤缺失，伴有严重的败血症并发症，需要应用培养的角质形成细胞和/或自体皮肤移植。我们采用了针对非烧伤患者的烧伤治疗方案的多学科方法，包括在制备不同类型生物敷料时与组织库密切合作。
