环孢素对肾移植受者血浆中纤维蛋白溶解调节因子的影响。

The effect of cyclosporine on regulators of fibrinolysis in plasma from renal allograft recipients.

作者信息

Elhasade A S, Perkowska A, Paczek L, Rowiński W, Soluch L, Szmidt J, Gałazka Z, Gaciong Z

机构信息

Transplantation Institute, Warsaw School of Medicine.

出版信息

Ann Transplant. 1998;3(1):13-8.

PMID:9869892

Abstract

Fibrinolytic disturbances are thought to play an important role in processes leading to deterioration of renal allograft function. We investigated the effect of CsA therapy on the regulation of fibrinolysis in kidney graft recipients by measuring plasma concentration and activity of plasminogen activators (tPA, uPA) and their inhibitors (PAI-1, 2). We found an increase in tPA activity and in PAI-1 concentration as well as a decrease in PAI-1 activity in renal allograft recipients as compared to healthy controls, but did not confirm a correlation between these observations and CsA administration. tPA and PAI-2 concentrations as well as uPA activity did not significantly differ between the studied groups. We showed a significant decrease in uPA plasma concentration in patients treated with azathioprine. The significance of this finding is unknown.

摘要

纤维蛋白溶解紊乱被认为在导致肾移植功能恶化的过程中起重要作用。我们通过测量纤溶酶原激活剂（组织型纤溶酶原激活剂、尿激酶型纤溶酶原激活剂）及其抑制剂（纤溶酶原激活物抑制剂-1、纤溶酶原激活物抑制剂-2）的血浆浓度和活性，研究了环孢素A治疗对肾移植受者纤维蛋白溶解调节的影响。我们发现，与健康对照组相比，肾移植受者的组织型纤溶酶原激活剂活性和纤溶酶原激活物抑制剂-1浓度增加，纤溶酶原激活物抑制剂-1活性降低，但未证实这些观察结果与环孢素A给药之间存在相关性。研究组之间组织型纤溶酶原激活剂和纤溶酶原激活物抑制剂-2浓度以及尿激酶型纤溶酶原激活剂活性无显著差异。我们发现接受硫唑嘌呤治疗的患者尿激酶型纤溶酶原激活剂血浆浓度显著降低。这一发现的意义尚不清楚。