Jacobs B L, Cohen A
J Comp Physiol Psychol. 1976 Jan;90(1):102-8. doi: 10.1037/h0077262.
Electrolytic lesions were placed in either the dorsal or median raphe nuclei of adult male albino rats. Both lesions produced significant reductions in forebrain serotonin levels. Lesions of the dorsal nucleus produced a long-lasting increase in pain-elicited aggression, whereas median lesions were without effect. By contrast, lesions of the median nucleus produced significant increases in open-field activity, which began immediately and lasted for at least 3 mo, whereas lesions of the dorsal nucleus had no such effect. Similarly, when animals with dorsal or sham lesions were tested in an open field and then given a brief noncontingent footshock, their open-field activity was markedly reduced on the following day. Median animals, however, showed little or no decrease in open-field activity on the day after footshock. These results suggest that the serotonin-containing neurons of the median raphe nucleus may exert an influence over the emotional responsivity of the rat. The overall results of these experiments extend our previous reports that lesions specific to the dorsal nucleus produce markedly different behavioral effects than lesions confined to the median nucleus. They also challenge the utility of manipulations that fail to take this into account, e.g., lesions of more than one nucleus or depletion of serotonin throughout the central nervous system.
对成年雄性白化大鼠的背侧或中缝核进行电解损伤。两种损伤均使前脑血清素水平显著降低。背侧核损伤导致疼痛引发的攻击行为长期增加，而中缝核损伤则无此效应。相比之下，中缝核损伤使旷场活动显著增加，这种增加立即出现并持续至少3个月，而背侧核损伤则无此作用。同样，当对有背侧损伤或假损伤的动物进行旷场测试，然后给予短暂的非条件性足部电击时，它们在第二天的旷场活动明显减少。然而，中缝核损伤的动物在电击后第二天的旷场活动几乎没有减少或没有减少。这些结果表明，中缝核中含血清素的神经元可能对大鼠的情绪反应性产生影响。这些实验的总体结果扩展了我们之前的报告，即背侧核特异性损伤产生的行为效应与局限于中缝核的损伤明显不同。它们还对未考虑到这一点的操作的效用提出了挑战，例如，多个核的损伤或整个中枢神经系统血清素的耗竭。
