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Phthalimidomethyl as a drug pro-moiety. Probing its reactivity.

作者信息

Iley J, Calheiros T, Moreira R

机构信息

Chemistry Department, Open University, Milton Keynes, U.K.

出版信息

Bioorg Med Chem Lett. 1998 Apr 21;8(8):955-8. doi: 10.1016/s0960-894x(98)00135-8.

DOI:10.1016/s0960-894x(98)00135-8
PMID:9871519
Abstract

Phthalimidomethyl derivatives 1, encompassing a wide range of leaving group abilities, are rapidly hydrolysed to the corresponding phthalamic acid via rate-determining attack at the phthalimide carbonyl group.

摘要

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