Kim S W, Hong C Y, Lee K, Lee E J, Koh J S
Biotech Research Institute, LG Chemical Ltd./Research Park Science Town, Taejon, Korea.
Bioorg Med Chem Lett. 1998 Apr 7;8(7):735-8. doi: 10.1016/s0960-894x(98)00114-0.
Using solid phase synthesis, a library has been constructed of benzylamine-derived sulfonamides which have strong inhibitory activity against the blood coagulant thrombin. The library compounds were obtained in good yield and high purity; four of these thrombin inhibitors showed nanomolar potency (Ki 600-10 nM).
