如分子模拟研究所示，苦杏仁苷与CD4受体结合。

Amygdalin binds to the CD4 receptor as suggested from molecular modeling studies.

作者信息

Llorens O, Filizola M, Spisani S, Marastoni M, Herranz C, Perez J J

机构信息

Dept. d'Enginyeria Quimica, Universitat Politecnica de Catalunya, ETSEIB, Barcelona, Spain.

出版信息

Bioorg Med Chem Lett. 1998 Apr 7;8(7):781-6. doi: 10.1016/s0960-894x(98)00120-6.

DOI:10.1016/s0960-894x(98)00120-6

PMID:9871541

Abstract

The geometrical features of the proposed bioactive conformation of peptide T assessed by computational methods in a previous study, together with available structure-activity studies on peptide T, led us to propose a pharmacophore for the CD4-peptide T interaction. Subsequent, data base searching permitted us to identify amygdalin as a peptide T peptidomimetic.

摘要

在先前一项研究中通过计算方法评估的肽T的拟生物活性构象的几何特征，以及关于肽T的现有构效关系研究，促使我们提出了CD4与肽T相互作用的药效团。随后，数据库检索使我们能够鉴定苦杏仁苷为肽T的拟肽。