Marastoni M, Salvadori S, Balboni G, Scaranari V, Spisani S, Reali E, Traniello S, Tomatis R
Department of Pharmaceutical Sciences, University of Ferrara, Italy.
Int J Pept Protein Res. 1993 May;41(5):447-54. doi: 10.1111/j.1399-3011.1993.tb00464.x.
Using the potent cyclic peptide T analog [formula: see text] as parent compound, a series of analogues were synthesized and their potencies in a monocyte chemotaxis assay were compared with those of correspondingly modified linear peptides. Structure-activity relationships observed with cyclic compounds did not always parallel those determined with linear analogues. [formula: see text] showed the highest affinity to CD4 receptor of monocytes of any peptide thus far studied. It also proved to be highly resistant to degradation by plasma or brain enzymes.
