包含高亲和力P2配体和（R）-（羟乙氨基）磺酰胺电子等排体的强效HIV蛋白酶抑制剂。
Potent HIV protease inhibitors incorporating high-affinity P2-ligands and (R)-(hydroxyethylamino)sulfonamide isostere.
作者信息
Ghosh A K, Kincaid J F, Cho W, Walters D E, Krishnan K, Hussain K A, Koo Y, Cho H, Rudall C, Holland L, Buthod J
机构信息
Department of Chemistry, University of Illinois at Chicago 60607, USA.
出版信息
Bioorg Med Chem Lett. 1998 Mar 17;8(6):687-90. doi: 10.1016/s0960-894x(98)00098-5.
PMID:9871583
Abstract
Design and synthesis of a series of very potent nonpeptide HIV protease inhibitors are described. The inhibitors are derived from novel high affinity P2-ligands and (R)-(hydroxyethylamino)sulfonamide isostere.
摘要
描述了一系列高效非肽类HIV蛋白酶抑制剂的设计与合成。这些抑制剂源自新型高亲和力P2配体和（R）-（羟乙氨基）磺酰胺电子等排体。
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