Synthesis and cytotoxic activity of novel 10-alkylated docetaxel analogs.
作者信息
Nakayama K, Terasawa H, Mitsui I, Ohsuki S, Uoto K, Iimura S, Soga T
机构信息
New Product Research Laboratories IV, Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan.
出版信息
Bioorg Med Chem Lett. 1998 Mar 3;8(5):427-32. doi: 10.1016/s0960-894x(98)00040-7.
PMID:9871592
Abstract
An alkylation method of docetaxel at the C-10 position has been established by a radical coupling reaction using a 10-xanthate derivative of 7-O-TES-10-deacetylbaccatin III and appropriate alkenes. In addition the cytotoxic activity of 10-alkylated docetaxel analogs was evaluated. Among these analogs, a derivative having a methoxycarbonyl group at the end of the alkyl moiety exhibited more potent cytotoxic activity than docetaxel.
摘要
Zotero 插件