基于异羟肟酸酯的低亲和力IgE受体（CD23）加工抑制剂。

Hydroxamate-based inhibitors of low affinity IgE receptor (CD23) processing.

作者信息

Bailey S, Bolognese B, Buckle D R, Faller A, Jackson S, Louis-Flamberg P, McCord M, Mayer R J, Marshall L A, Smith D G

机构信息

SmithKline Beecham Pharmaceuticals, Epsom, Surrey, UK.

出版信息

Bioorg Med Chem Lett. 1998 Jan 6;8(1):23-8. doi: 10.1016/s0960-894x(97)10148-2.

DOI:10.1016/s0960-894x(97)10148-2

PMID:9871622

Abstract

A series of hydroxamic acids related to the non-selective matrix metalloprotease inhibitor Batimastat is described, which inhibits the proteolytic cleavage of the low affinity IgE receptor from cell membrane preparations. Limited SAR studies suggest that the structural requirements for effective inhibition are distinct from those required for the inhibition of collagenase.

摘要

描述了一系列与非选择性基质金属蛋白酶抑制剂batimastat相关的异羟肟酸，其可抑制细胞膜制剂中低亲和力IgE受体的蛋白水解切割。有限的构效关系研究表明，有效抑制的结构要求与抑制胶原酶所需的结构要求不同。