低亲和力IgE受体（CD23）加工的选择性抑制。
Selective inhibition of low affinity IgE receptor (CD23) processing.
作者信息
Bailey S, Bolognese B, Buckle D R, Faller A, Jackson S, Louis-Flamberg P, McCord M, Mayer R J, Marshall L A, Smith D G
机构信息
SmithKline Beecham Pharmaceuticals, Epsom, Surrey, UK.
出版信息
Bioorg Med Chem Lett. 1998 Jan 6;8(1):29-34. doi: 10.1016/s0960-894x(97)10149-4.
A series of hydroxamic acids related to the non-selective matrix metalloproteinase inhibitor Batimastat has been prepared, some members of which are potent inhibitors of the processing of the low affinity IgE receptor (CD 23). Increased activity is obtained by appropriate substitution at the alpha-position, whilst selectivity is gained by use of a P1' benzyl group in conjunction with a C-terminal primary amide.
已经制备了一系列与非选择性基质金属蛋白酶抑制剂batimastat相关的异羟肟酸，其中一些成员是低亲和力IgE受体（CD 23）加工的有效抑制剂。通过在α位进行适当取代可提高活性，同时通过使用P1'苄基与C末端伯酰胺结合可获得选择性。
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