Armer R E, Dutton C J, Fenner B R, Greenwood S D, Hall K T, Rudge A J
Pfizer Central Research, Sandwich, Kent.
Bioorg Med Chem Lett. 1998 Jan 20;8(2):139-42. doi: 10.1016/s0960-894x(97)10200-1.
Carbocyclic analogues of the antibacterial natural product frenolicin B have been synthesised. These analogues were active against parasitic protozoa of the genus Eimeria and represent a new series of anticoccidial agents. The synthesis of simplified analogues helped to define a possible pharmacophore for frenolicin.
抗菌天然产物弗雷诺利菌素B的碳环类似物已被合成。这些类似物对艾美耳属的寄生原生动物具有活性，代表了一系列新的抗球虫剂。简化类似物的合成有助于确定弗雷诺利菌素可能的药效团。
