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具有强效广谱抗原虫活性的新型抗疟羟基萘醌。

Novel anti-malarial hydroxynaphthoquinones with potent broad spectrum anti-protozoal activity.

作者信息

Hudson A T, Randall A W, Fry M, Ginger C D, Hill B, Latter V S, McHardy N, Williams R B

出版信息

Parasitology. 1985 Feb;90 ( Pt 1):45-55. doi: 10.1017/s0031182000049003.

DOI:10.1017/s0031182000049003
PMID:3920634
Abstract

Novel hydroxynaphthoquinones are reported with outstanding efficacy against Plasmodium, Eimeria and Theileria species. Biochemical evidence is presented for the selective toxicity of these compounds being due to inhibition of parasite respiratory systems.

摘要

据报道，新型羟基萘醌对疟原虫、艾美球虫和泰勒虫具有显著疗效。本文提供了生化证据，证明这些化合物的选择性毒性是由于抑制寄生虫呼吸系统所致。

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