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Inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT) as hypocholesterolemic agents: synthesis and structure-activity relationships of novel series of sulfonamides, acylphosphonamides and acylphosphoramidates.

作者信息

Lee H T, Roark W H, Picard J A, Sliskovic D R, Roth B D, Stanfield R L, Hamelehle K L, Bousley R F, Krause B R

机构信息

Department of Medicinal Chemistry, Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Ann Arbor, Michigan 48105, USA.

出版信息

Bioorg Med Chem Lett. 1998 Feb 3;8(3):289-94. doi: 10.1016/s0960-894x(98)00011-0.

DOI:10.1016/s0960-894x(98)00011-0
PMID:9871672
Abstract

Sulfoacetic acid, phosphoramidate, and phosphoramide analogs of the ACAT inhibitors, CI-999 and CI-1011 were synthesized. The structure-activity relationships of these compounds as ACAT inhibitors are described.

摘要

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