青蒿素缩醛和非缩醛型类似物在模拟胃酸中的稳定性。
Stability of acetal and non acetal-type analogs of artemisinin in simulated stomach acid.
作者信息
Jung M, Lee S
机构信息
Department of Chemistry, Yonsei University, Seoul, Korea.
出版信息
Bioorg Med Chem Lett. 1998 May 5;8(9):1003-6. doi: 10.1016/s0960-894x(98)00160-7.
PMID:9871697
Abstract
A series of non acetal-type analogs of artemisinin containing C-C bond at position-12 have been found to be 15-22 times more stable than acetal(C-O)-type prodrugs of artemisinin in simulated stomach acid.
摘要
已发现一系列在12位含有C-C键的青蒿素非缩醛型类似物在模拟胃酸中比青蒿素的缩醛（C-O）型前药稳定15至22倍。
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