具有新型羧酰胺甲基膦酰胺和甘氨酰胺核苷间连接键的DNA类似物的合成。
Synthesis of DNA analogues with novel carboxamidomethyl phosphonamide and glycinamide internucleoside linkages.
作者信息
Efimov V A, Buryakova A A, Chakhmakhcheva O G
机构信息
Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
出版信息
Bioorg Med Chem Lett. 1998 May 5;8(9):1013-8. doi: 10.1016/s0960-894x(98)00153-x.
PMID:9871699
Abstract
Thymidine oligonucleotide analogues with phosphodiester bonds fully substituted by carboxamidomethyl phosphonamide, or glycinamide linkages were synthesized on a solid support, and their hybridization properties toward DNA and RNA targets were determined by Tm analysis.
摘要
在固相载体上合成了磷酸二酯键完全被羧酰胺甲基膦酰胺或甘氨酰胺键取代的胸苷寡核苷酸类似物，并通过熔解温度分析确定了它们对DNA和RNA靶标的杂交特性。
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