热稳定DNA聚合酶对非标准碱基对的识别。
Recognition of a non-standard base pair by thermostable DNA polymerases.
作者信息
Lutz M J, Horlacher J, Benner S A
机构信息
Department of Chemistry, ETH Zürich, Switzerland.
出版信息
Bioorg Med Chem Lett. 1998 May 19;8(10):1149-52. doi: 10.1016/s0960-894x(98)00177-2.
PMID:9871725
Abstract
Examination of several commercially available thermostable DNA polymerases identifies 9 degrees N DNA polymerase as single enzyme that could incorporate two components of an expanded genetic alphabet, 2,4-diaminopyrimidine and xanthosine as deoxynucleoside triphosphate opposite their cognate base in a DNA template.
摘要
对几种市售热稳定DNA聚合酶进行检测后发现，9°N DNA聚合酶是唯一一种能够将扩展遗传字母表的两个组分，即2,4-二氨基嘧啶和黄嘌呤核苷三磷酸掺入DNA模板中与其同源碱基相对应位置的酶。
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