[(2'S, 3'S)-双(羟甲基)吡咯烷-1-基]嘌呤和嘧啶核苷作为潜在抗病毒剂的合成
Synthesis of [(2'S, 3'S)-bis(hydroxylmethyl)pyrrolidin-1-yl] purine and pyrimidine nucleosides as potential antiviral agents.
作者信息
Oohashi T, Nishiyama S, Yamamura S, Kato K
机构信息
Department of Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan.
出版信息
Bioorg Med Chem Lett. 1998 May 19;8(10):1187-8. doi: 10.1016/s0960-894x(98)00193-0.
PMID:9871732
Abstract
The enantiomerically pure synthesis of [(2'S, 3'S)-bis(hydroxymethyl)pyrrolidin-1-yl] thymine 17 and -adenine 20 was achieved via construction of the base on the 1-amino-pyrrolidine 15, and their anti-HSV-1 and -2, and anti-HIV-1 activities were evaluated.
摘要
通过在1-氨基吡咯烷15上构建碱基，实现了[(2'S, 3'S)-双(羟甲基)吡咯烷-1-基]胸腺嘧啶17和腺嘌呤20的对映体纯合成，并评估了它们对单纯疱疹病毒1型和2型以及人类免疫缺陷病毒1型的活性。
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