作为潜在抗病毒药物的碳环核苷的合成。
Synthesis of carbocyclic nucleosides as potential antiviral agents.
作者信息
Kozaki A, Zulfiqar F, Ueno Y, Kitade Y
机构信息
Laboratory of Molecular Biochemistry, Department of Biomolecular Science, Faculty of Engineering, Gifu University, Yanagido 1-1, Gifu 501-1193, Japan.
出版信息
Nucleic Acids Res Suppl. 2001(1):59-60. doi: 10.1093/nass/1.1.59.
Treatment of 1-[(1'R,2'S,3'S,4'S)-4'-methanesulfonyl-2',3'-O- isopropylidenedioxycyclopentan-1'-yl]-1-H-uracil with LiN3 gave 1-[(1'R,2'S,3'R)-2',3'-O-isopropylidenedioxy-4'- cyclopenten-1'-yl]-1-H-uracil. When KOBut was added instead of LiN3, 1-[(1'R,2'S)-2',3'-O- isopropylidenedioxy-3'-cyclopenten-1'-yl]-1-H-uracil was produced. An analogous treatment of the methanesulfonyl derivative of thymine was also carried out.
用叠氮化锂处理1-[(1'R,2'S,3'S,4'S)-4'-甲磺酰基-2',3'-O-异丙叉二氧基环戊烷-1'-基]-1-H-尿嘧啶，得到1-[(1'R,2'S,3'R)-2',3'-O-异丙叉二氧基-4'-环戊烯-1'-基]-1-H-尿嘧啶。当加入叔丁醇钾代替叠氮化锂时，生成1-[(1'R,2'S)-2',3'-O-异丙叉二氧基-3'-环戊烯-1'-基]-1-H-尿嘧啶。还对胸腺嘧啶的甲磺酰基衍生物进行了类似处理。
Zotero 插件