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1-脱氧-3-S-（1-硫代-α-D-吡喃葡萄糖基）-甘露基胺基脱氧野尻霉素和1-脱氧-3-O-（5-硫代-α-D-吡喃葡萄糖基）-甘露基胺基脱氧野尻霉素的合成作为内切-α-D-甘露糖苷酶的潜在抑制剂

Syntheses of 1-deoxy-3-s-(1-thio-alpha-D-glucopyranosyl)-mannojirimycin and 1-deoxy-3-O-(5-thio-alpha-D-glucopyranosyl)-mannojirimycin as potential inhibitors of endo-alpha-D-mannosidase.

作者信息

Ding Y, Hindsgaul O

机构信息

Burnham Institute, La Jolla Cancer Research Center, CA 92037, USA.

出版信息

Bioorg Med Chem Lett. 1998 May 19;8(10):1215-20. doi: 10.1016/s0960-894x(98)00198-x.

DOI:10.1016/s0960-894x(98)00198-x
PMID:9871738
Abstract

1-Deoxy-3-S-(1-thio-alpha-D-glucopyranosyl)-mannojirimycin and 1-deoxy-3-O-(5-thio-alpha-D-glucopyranosyl) mannojirimycin were chemically synthesized as potential inhibitors of endo-alpha-D-mannosidase.

摘要

1-脱氧-3-S-(1-硫代-α-D-吡喃葡萄糖基)-甘露基脱氧野尻霉素和1-脱氧-3-O-(5-硫代-α-D-吡喃葡萄糖基)甘露基脱氧野尻霉素作为内切-α-D-甘露糖苷酶的潜在抑制剂被化学合成。

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Syntheses of 1-deoxy-3-s-(1-thio-alpha-D-glucopyranosyl)-mannojirimycin and 1-deoxy-3-O-(5-thio-alpha-D-glucopyranosyl)-mannojirimycin as potential inhibitors of endo-alpha-D-mannosidase.1-脱氧-3-S-（1-硫代-α-D-吡喃葡萄糖基）-甘露基胺基脱氧野尻霉素和1-脱氧-3-O-（5-硫代-α-D-吡喃葡萄糖基）-甘露基胺基脱氧野尻霉素的合成作为内切-α-D-甘露糖苷酶的潜在抑制剂
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