用于取代核苷酸磷酸二酯的异恶唑和异恶唑啉连接键的设计与合成。
Design and synthesis of isoxazole and isoxazoline linkage for replacement of nucleotide phosphodiester.
作者信息
Kim S J, Lee J Y, Kim B H
机构信息
Department of Chemistry, Pohang University of Science and Technology, Korea.
出版信息
Bioorg Med Chem Lett. 1998 Jun 2;8(11):1313-6. doi: 10.1016/s0960-894x(98)00210-8.
PMID:9871757
Abstract
Synthetic routes for oligonucleotides which have isoxazoline or isoxazole linkage have been developed, and di- and tri-nucleotides with thymine bases have been prepared.
摘要
已经开发出具有异恶唑啉或异恶唑键的寡核苷酸的合成路线，并制备了含有胸腺嘧啶碱基的二核苷酸和三核苷酸。
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