Klar U, Graf H, Schenk O, Röhr B, Schulz H
Research Laboratories of Schering AG, Berlin, Germany.
Bioorg Med Chem Lett. 1998 Jun 2;8(11):1397-402. doi: 10.1016/s0960-894x(98)00226-1.
A new class of borneol esters that might be considered as biological analogs of paclitaxel regarding their action on microtubules has been found. By structure-activity optimizations, compounds stabilizing microtubules much better than paclitaxel while showing a remarkably reduced cytotoxic activity were obtained. This dissoziation will open completely new therapeutic areas.
