Imanishi J, Kita M, Yamaoka Y, Sawai N, Tanahashi T, Kodama T
Département de Microbiologie, Université Médicale de la Préfecture de Kyoto, Japon.
C R Seances Soc Biol Fil. 1998;192(5):991-6.
It is well known that Helicobacter pylori can cause gastritis, gastroduodenal ulcers and malignant diseases. The infiltration of polymorphonuclear leukocytes is recognized in the lesions of these diseases, and the infiltration disappears by antibiotic therapy. However, it is not yet clarified how Helicobacter pylori induces the formation of lesions including leukocyte infiltration. Recently, we have confirmed that several kinds of cytokines are expressed in the gastric biopsy specimens of gastroduodenal diseases. Especially, it is conjectured that chemokines such as interleukin-8 (IL-8) which are expressed in the specimens, induce leukocyte infiltration, gastric mucosal inflammation and gastroduodenal ulcers. It is possible that Helicobacter pylori CagA gene is closely related with IL-8 expression because this cytokine is more strongly expressed in the specimens from the patients infected with CagA-positive Helicobacter than those with CagA-negative one.
众所周知，幽门螺杆菌可引发胃炎、胃十二指肠溃疡及恶性疾病。在这些疾病的病变部位可识别出多形核白细胞浸润，且通过抗生素治疗浸润会消失。然而，幽门螺杆菌如何诱导包括白细胞浸润在内的病变形成尚未明确。最近，我们已证实几种细胞因子在胃十二指肠疾病的胃活检标本中表达。特别是，推测标本中表达的趋化因子如白细胞介素-8（IL-8）可诱导白细胞浸润、胃黏膜炎症和胃十二指肠溃疡。幽门螺杆菌CagA基因可能与IL-8表达密切相关，因为与感染CagA阴性幽门螺杆菌的患者标本相比，这种细胞因子在感染CagA阳性幽门螺杆菌患者的标本中表达更强。
