Nozaki-Renard J, O'Leary J, Zolla-Pazner S, Tada T
Department of Microbiology, Tokyo Medical College.
C R Seances Soc Biol Fil. 1998;192(5):1007-15.
Having reported that HIV-1-infected T cell lines are rescued as CD4- from cytolysis by human complement factor B, we now show the presence of an in vivo counterpart of such CD4- T cells by demonstrating the circulating CD3+ CD4- CD8- CD29+ cells in the blood of seropositive subjects (n = 91, classified by the immunologic scale scores 0, 1, 2 and 3). The cell population was found to be significantly increased in the early phase of infection in score 0: 195/mm3 (p < 0.005) and in score 1:376/mm3 (p = 0.001). With the infection progressing to score 2, the cells decreased to 220/mm3 (p < 0.001) and finally to the same range: 101/mm3, as that of uninfected subjects. Further elucidation of the mechanism of the appearance and disappearance of that population in vivo could help to elucidate protective immunologic processes.
我们曾报道，人类补体因子B可使感染HIV-1的T细胞系免受细胞溶解，从而以CD4-形式得到拯救。现在，我们通过在血清反应阳性受试者（n = 91，根据免疫量表评分为0、1、2和3进行分类）的血液中检测循环CD3+ CD4- CD8- CD29+细胞，证实了此类CD4- T细胞在体内的对应物的存在。发现在感染早期，免疫量表评分为0时，该细胞群体显著增加至195/mm3（p < 0.005），评分为1时为376/mm3（p = 0.001）。随着感染进展至评分为2，这些细胞减少至220/mm3（p < 0.001），最终降至与未感染受试者相同的范围：101/mm3。进一步阐明该群体在体内出现和消失的机制，可能有助于阐明保护性免疫过程。
