Gangadhar B N, Girish K, Janakiramiah N, Subbakrishna D K, Parameshwara G, Prasad K M
Department of Psychiatry, National Institute of Mental Health and Neuro Sciences, Bangalore, India.
J ECT. 1998 Dec;14(4):259-65.
Seizure thresholds were determined by titration in consecutive electroconvulsive therapy (ECT) patients at the first (n = 146) and sixth (N = 83) ECT sessions. Equations to predict the threshold at the first and sixth ECT were computed from these data using a stepwise linear regression model. These equations were tested prospectively at the first ECT (n = 48) and sixth ECT (n = 26) sessions. Stimulus dose derived from the corresponding equations yielded adequate seizure (successful) in 82% and 84% of patients, respectively. Predictions based on age alone (disregarding two other significant variables--illness severity and inion-nasion distance) were estimated at these two ECT sessions. This would not appreciably compromise the success rate. The "formula" method using age alone may therefore be used in routine clinical practice.
在首次（n = 146）和第六次（N = 83）电休克治疗（ECT）时，通过滴定法测定了连续ECT患者的癫痫发作阈值。使用逐步线性回归模型从这些数据中计算出预测首次和第六次ECT时阈值的方程。这些方程在首次ECT（n = 48）和第六次ECT（n = 26）时进行了前瞻性测试。从相应方程得出的刺激剂量分别在82%和84%的患者中产生了足够的癫痫发作（成功）。在这两次ECT时估计了仅基于年龄（忽略另外两个重要变量——疾病严重程度和枕外隆凸-鼻根距离）的预测。这不会明显影响成功率。因此，仅使用年龄的“公式”方法可用于常规临床实践。
