Beale M D, Kellner C H, Pritchett J T, Bernstein H J, Burns C M, Knapp R
Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston 29425.
Convuls Ther. 1994 Jun;10(2):171-6.
One hundred and thirty-four patients referred for electroconvulsive therapy (ECT) over a 2-year period underwent standardized stimulus dose-titration. No significant adverse events were associated with the dose-titration procedure. Our data demonstrate that seizure threshold increases with age (p = 0.0001) and is higher with bilateral electrode placement (p = 0.0001). Contrary to other studies, our data show the effect of gender is not statistically significant (p = 0.54). If consensus regarding optimal dosing strategies relative to seizure threshold can be achieved, dose-titration may be adopted as a clinically useful step in optimizing ECT technique.
在两年期间转诊接受电休克治疗（ECT）的134例患者接受了标准化刺激剂量滴定。剂量滴定过程未发生显著不良事件。我们的数据表明，癫痫发作阈值随年龄增加而升高（p = 0.0001），双侧电极放置时癫痫发作阈值更高（p = 0.0001）。与其他研究相反，我们的数据显示性别影响无统计学意义（p = 0.54）。如果能够就相对于癫痫发作阈值的最佳给药策略达成共识，剂量滴定可作为优化ECT技术的一个临床有用步骤。
