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肺炎克雷伯菌临床分离株:对某些抗生素的敏感性及表面疏水性

Klebsiella pneumoniae clinical isolates: susceptibility to some antibiotics and surface hydrophobicity.

作者信息

Hostacká A, Síposová E

机构信息

Institute of Preventive and Clinical Medicine, Bratislava, Slovak Republic.

出版信息

Microbios. 1998;95(381):101-7.

PMID:9871999
Abstract

The susceptibility of Klebsiella pneumoniae strains isolated from the respiratory tract (55), urinary tract (19) and other human body sites (8) to the antibiotics, amoxycillin/clavulanate, cefuroxime, ceftazidime, gentamicin, norfloxacin, colistine, cotrimoxazole and oxolinic acid, as well as their surface hydrophobicity, were studied. The strains expressed a very high sensitivity to the antibiotics (94.7-100%). The surface hydrophobicity of the strains was evaluated by means of three assays and was minimal. The hydrophobicity manifested by adherence to xylene ranged between 0 and 10% for 96.4% of the respiratory strains, and for 100% of the urinary and other sites. Weak binding of Congo red (10-29 micrograms/10(10) cells) showed 96.4% of respiratory isolates as well as 100% of the urinary and other strains. Results of the salt aggregation test showed that 96.4% of respiratory strains and 100% of urinary and other strains aggregated only at 1.5 M, 2 M or higher concentrations.

摘要

对从呼吸道(55株)、泌尿道(19株)及其他人体部位(8株)分离出的肺炎克雷伯菌菌株,研究了其对阿莫西林/克拉维酸、头孢呋辛、头孢他啶、庆大霉素、诺氟沙星、黏菌素、复方新诺明和恶喹酸等抗生素的敏感性及其表面疏水性。这些菌株对这些抗生素表现出很高的敏感性(94.7 - 100%)。通过三种测定方法评估了菌株的表面疏水性,结果显示其表面疏水性很低。对于96.4%的呼吸道菌株,以及100%的泌尿道和其他部位菌株,通过二甲苯吸附法测定的疏水性在0至10%之间。96.4%的呼吸道分离株以及100%的泌尿道和其他菌株表现出刚果红弱结合(10 - 29微克/10¹⁰个细胞)。盐聚集试验结果表明,96.4%的呼吸道菌株以及100%的泌尿道和其他菌株仅在1.5M、2M或更高浓度下聚集。

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