Hostacká A
Institute of Preventive and Clinical Medicine, Bratislava, Slovak Republic.
Microbios. 1997;91(368-369):137-43.
Cell surface hydrophobicity and serum sensitivity of Klebsiella pneumoniae, after treatment with sub-minimum inhibitory concentrations (sub-MICs) of ciprofloxacin, norfloxacin and enoxacin, were studied. The quinolones tested at 1/4, 1/8 and 1/16 of the MICs decreased surface hydrophobicity. The most significant reduction of the bacterial cell surface hydrophobicity was found after treatment with antibiotics at 1/16 of the MICs (to 20.3% for both ciprofloxacin and norfloxacin, and to 23.6% for enoxacin, compared with control values). The most significant increase in the susceptibility of the bacteria to serum bactericidal activity was seen after 180 min incubation with ciprofloxacin and enoxacin at 1/16 of their MICs. Survival of treated bacteria was 55 +/- 8% 56 +/- 10% as compared with controls without antibiotics.
研究了用环丙沙星、诺氟沙星和依诺沙星的亚最小抑菌浓度（亚 MIC）处理后肺炎克雷伯菌的细胞表面疏水性和血清敏感性。在 MIC 的 1/4、1/8 和 1/16 浓度下测试的喹诺酮类药物降低了表面疏水性。在用 MIC 的 1/16 浓度的抗生素处理后，发现细菌细胞表面疏水性降低最为显著（环丙沙星和诺氟沙星均降至 20.3%，依诺沙星降至 23.6%，与对照值相比）。在用环丙沙星和依诺沙星的 MIC 的 1/16 浓度孵育 180 分钟后，观察到细菌对血清杀菌活性的敏感性增加最为显著。与未用抗生素的对照相比，处理后细菌的存活率为 55±8%和 56±10%。
