Sluijmer A V, Heineman M J, Koudstaal J, Theunissen P H, de Jong F H, Evers J L
Department of Obstetrics and Gynecology, Wilhelmina Ziekenhuis, Assen, The Netherlands.
Menopause. 1998 Winter;5(4):207-10.
To study the relationship between ovarian production of estrone (E ), estradiol (E2), testosterone (T), and androstenedione (A) and the ovarian degree of stromal hyperplasia in postmenopausal women.
In 18 postmenopausal women, the ovarian vein hormone levels of E1, E2, T, and A were compared with the degree of ovarian stromal hyperplasia. The degree of stromal hyperplasia was assessed by histological analysis (group 1: atrophic ovaries, n = 8; group 2: slight stromal hyperplasia, n = 8; group 3: moderate or severe stromal hyperplasia, n = 2).
The ovarian levels of E1 and E2 did not correlate with the ovarian degree of stromal hyperplasia. The ovarian levels of A in group 3 were significantly higher than those in groups 1 and 2 (p < 0.02 and p < 0.01, respectively). The ovarian levels of T in group 3 were significantly higher than those in group 1 (p < 0.01) but did not differ significantly from those in group 2.
The amount of stromal hyperplasia in postmenopausal ovaries is correlated with the ovarian vein levels of A and T. Morphological characteristics of the postmenopausal ovary determine the local (pelvic) endocrine status and may play a role in the etiology of hormone-dependent diseases of the internal genitals.
研究绝经后女性卵巢分泌雌酮（E₁）、雌二醇（E₂）、睾酮（T）及雄烯二酮（A）与卵巢基质增生程度之间的关系。
对18名绝经后女性，比较其卵巢静脉中E₁、E₂、T及A的激素水平与卵巢基质增生程度。通过组织学分析评估基质增生程度（第1组：萎缩性卵巢，n = 8；第2组：轻度基质增生，n = 8；第3组：中度或重度基质增生，n = 2）。
卵巢E₁和E₂水平与卵巢基质增生程度无关。第3组卵巢A水平显著高于第1组和第2组（分别为p < 0.02和p < 0.01）。第3组卵巢T水平显著高于第1组（p < 0.01），但与第2组无显著差异。
绝经后卵巢基质增生量与卵巢静脉中A和T水平相关。绝经后卵巢的形态特征决定局部（盆腔）内分泌状态，并可能在内生殖器激素依赖性疾病的病因学中起作用。
