Doshi Sejal B, Agarwal Ashok
Department of Andrology, Center for Reproductive Medicine, Cleveland Clinic, Cleveland, Ohio, USA.
J Midlife Health. 2013 Jul;4(3):140-6. doi: 10.4103/0976-7800.118990.
This review will discuss the concept of reproductive aging, which includes the definition of menopause, its symptoms, and predisposing conditions. It will elaborate upon the contributory factors implicated in the pathogenesis of menopause, focusing most prominently on oxidative stress. Specifically, this paper will explain how oxidative stress, in the form of free radicals and antioxidant deficiencies, has been directly linked to the decline of estrogen during reproductive aging. Additionally, this paper will elaborate upon the treatment options aimed at mitigating the menopausal symptoms and hormonal deficiencies that can lead to various disease processes. Treatment options such as hormonal therapy, antioxidant supplementation, and lifestyle modification have been explored for their effectiveness in treating and preventing the symptoms and sequelae of menopause. The majority of information in this review was obtained through PubMed and the National Library of Medicine. While most references in this paper are original research articles, a limited number of references are comprehensive reviews on the topic.
本综述将讨论生殖衰老的概念，其中包括绝经的定义、症状和易感条件。它将详细阐述与绝经发病机制相关的促成因素，最主要关注氧化应激。具体而言，本文将解释自由基和抗氧化剂缺乏形式的氧化应激如何与生殖衰老期间雌激素的下降直接相关。此外，本文将详细阐述旨在减轻可导致各种疾病过程的绝经症状和激素缺乏的治疗选择。已探讨了激素疗法、补充抗氧化剂和生活方式改变等治疗选择在治疗和预防绝经症状及后遗症方面的有效性。本综述中的大部分信息是通过PubMed和国家医学图书馆获得的。虽然本文中的大多数参考文献是原创研究文章，但也有少数参考文献是关于该主题的综合综述。
