Jiang P, Lagenaur C F, Narayanan V
Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA.
J Biol Chem. 1999 Jan 8;274(2):559-62. doi: 10.1074/jbc.274.2.559.
P84 (also known as SHPS-1, BIT, and SIRP) is a heterophilic adhesive membrane protein involved in receptor tyrosine kinase signaling that is found at synapses in the mammalian central nervous system and in non-neural tissues. We have identified a binding partner for P84 using an expression cloning strategy. Here we report that integrin-associated protein (IAP/CD47) is a predominant binding partner of P84. Immunohistochemistry reveals a virtually identical distribution of P84 and IAP in a variety of adult brain regions. Because IAP has been implicated in cell signaling in cells of the immune system, P84 and IAP represent a heterophilic binding pair that is likely to be involved in bi-directional signaling at the synapse and in other tissues.
P84（也称为SHPS-1、BIT和SIRP）是一种参与受体酪氨酸激酶信号传导的异嗜性粘附膜蛋白，存在于哺乳动物中枢神经系统的突触和非神经组织中。我们采用表达克隆策略鉴定出了P84的一个结合伴侣。在此我们报告，整合素相关蛋白（IAP/CD47）是P84的主要结合伴侣。免疫组织化学显示，P84和IAP在多种成人大脑区域的分布几乎相同。由于IAP已被证实参与免疫系统细胞的信号传导，P84和IAP代表了一个异嗜性结合对，可能参与突触和其他组织中的双向信号传导。
