Comu S, Weng W, Olinsky S, Ishwad P, Mi Z, Hempel J, Watkins S, Lagenaur C F, Narayanan V
Department of Pediatrics, The Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania.
J Neurosci. 1997 Nov 15;17(22):8702-10. doi: 10.1523/JNEUROSCI.17-22-08702.1997.
P84 is a neuronal membrane glycoprotein that promotes the attachment and neurite outgrowth of cultured murine cerebellar cells. The heterophilic adhesive properties of P84 and its localization at sites of synaptogenesis suggest that it may be involved in regulation of synapse formation or maintenance. P84 is expressed in subsets of neurons throughout the CNS. By cloning the cDNA encoding murine P84, we have discovered that this molecule is a member of a family of phosphatase-binding proteins and is identical to the murine SHPS-1 cDNA. Here we report the cloning of two alternatively spliced forms of P84 and describe its localization within the CNS by in situ hybridization.
P84是一种神经元膜糖蛋白，可促进培养的小鼠小脑细胞的附着和神经突生长。P84的异嗜性粘附特性及其在突触形成部位的定位表明，它可能参与突触形成或维持的调节。P84在整个中枢神经系统的神经元亚群中表达。通过克隆编码小鼠P84的cDNA，我们发现该分子是磷酸酶结合蛋白家族的成员，并且与小鼠SHPS-1 cDNA相同。在此我们报告了P84的两种选择性剪接形式的克隆，并通过原位杂交描述了其在中枢神经系统中的定位。
