De Reuck J, Stevens H, Jansen H, Keppens J, Strijckmans K, Goethals P, Lemahieu I, Santens P, Korf J
PET Centre UZ/RUG, Department of Neurology, University Hospital of Ghent, Belgium.
Cerebrovasc Dis. 1999 Jan-Feb;9(1):40-4. doi: 10.1159/000015894.
Cobalt-55 (55Co) is a positron emission tomography (PET) tracer used to demonstrate brain damage, possibly associated to calcium-mediated processes. The degree of 55Co accumulation correlates with the severity of ischaemia in stroke patients. It is still a matter of debate whether ipsilateral thalamic hypometabolism (ITH) and crossed cerebellar hypometabolism (CCH), occurring after middle cerebral artery (MCA) infarcts, represent only a metabolic depression of these remote regions or can lead to structural damage. The present study investigates whether an increased 55Co influx can be demonstrated with PET in ITH and CCH after MCA infarcts. About half of the patients with ITH and CCH had a significant degree of 55Co uptake in, respectively, the ipsilateral thalamus and the contralateral cerebellar hemisphere. It was observed in patients with severe signs of stroke on admission and poor clinical outcome, and correlated well with the degree of 55Co influx within the supratentorial infarct. The present study demonstrates that ITH and CCH after MCA infarction can represent structural damage in these remote areas that occurs during the second week after stroke onset.
钴-55（⁵⁵Co）是一种正电子发射断层扫描（PET）示踪剂，用于显示可能与钙介导过程相关的脑损伤。⁵⁵Co的积聚程度与中风患者的缺血严重程度相关。大脑中动脉（MCA）梗死发生后出现的同侧丘脑代谢减退（ITH）和交叉小脑代谢减退（CCH），究竟仅仅代表这些远隔区域的代谢抑制，还是会导致结构损伤，目前仍存在争议。本研究调查了PET是否能显示MCA梗死患者ITH和CCH中⁵⁵Co流入增加。ITH和CCH患者中约一半分别在同侧丘脑和对侧小脑半球有显著程度的⁵⁵Co摄取。在入院时有严重中风体征且临床预后较差的患者中观察到了这种情况，并且与幕上梗死灶内的⁵⁵Co流入程度密切相关。本研究表明，MCA梗死患者ITH和CCH可代表中风发作后第二周在这些远隔区域发生的结构损伤。
