De Reuck J, Santens P, Keppens J, De Bleecker J, Strijckmans K, Goethals P, Lemahieu I, Korf J
PET Centre UZ/RUG, University Hospital, Gent, Belgium.
Clin Neurol Neurosurg. 1999 Mar;101(1):15-8. doi: 10.1016/s0303-8467(98)00076-6.
The present study investigates if Cobalt-55 (55Co) positron emission tomography (PET) allows us to distinguish and detect recent, recurrent strokes in patients who had already suffered a previous infarct in the same vascular territory. Fourteen patients with recurrent strokes underwent a 55Co PET scan of the brain. Recently infarcted areas, less than 2 months old, had a high 55Co uptake ratio, whereas infarcts of 6 months to 1 year had an uptake ratio comparable to normal brain tissue. In infarcts older than 2 years the 55Co uptake ratio was decreased compared to the control values. The evolution in 55Co uptake ratios with time can be explained by the dynamics of the inflammatory response within the infarct core. 55Co PET allows to demonstrate stroke recurrence and suggests that single photon emission tomography, using 57Co as the tracer, could be a more easy alternative to be used in routine neurological practice.
本研究调查了钴 - 55（⁵⁵Co）正电子发射断层扫描（PET）是否能使我们在已经在相同血管区域发生过梗死的患者中区分和检测近期复发性中风。14例复发性中风患者接受了脑部⁵⁵Co PET扫描。近期梗死区域（小于2个月）的⁵⁵Co摄取率较高，而6个月至1年的梗死灶摄取率与正常脑组织相当。在超过2年的梗死灶中，⁵⁵Co摄取率与对照值相比有所降低。⁵⁵Co摄取率随时间的变化可以用梗死核心内炎症反应的动态过程来解释。⁵⁵Co PET能够显示中风复发，并表明使用⁵⁷Co作为示踪剂的单光子发射断层扫描可能是在常规神经科实践中更易于使用的替代方法。
