Guilhou J
Service de Dermatologie-Phlébologie, Laboratoire de Dermatologie Moléculaire, Hôpital Saint-Eloi, Montpellier, France.
Dermatology. 1998;197(4):310-2. doi: 10.1159/000018022.
Twenty years ago, a concept of psoriasis pathogenesis was proposed in which epidermal proliferation of psoriatic lesions was the consequence of immunological abnormalities. This concept has subsequently been supported by the remarkable efficacy of immunosuppressive drugs. Moreover, recent experimental data indicate that activated psoriatic lymphocytes are capable of inducing keratinocyte proliferation. However, we have still to explain the mechanism by which lymphocytes act on keratinocytes and to find out what antigenic material could be responsible for their activation.
二十年前，有人提出了一种银屑病发病机制的概念，即银屑病皮损的表皮增殖是免疫异常的结果。这一概念随后得到了免疫抑制药物显著疗效的支持。此外，最近的实验数据表明，活化的银屑病淋巴细胞能够诱导角质形成细胞增殖。然而，我们仍需解释淋巴细胞作用于角质形成细胞的机制，并找出可能导致其活化的抗原物质。
