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Synthesis and preliminary evaluation of (S)-2-(4'-carboxycubyl)glycine, a new selective mGluR1 antagonist.

作者信息

Pellicciari R, Costantino G, Giovagnoni E, Mattoli L, Brabet I, Pin J P

机构信息

Istituto di Chimica e Tecnologia del Farmaco, Università degli Studi, Perugia, Italy.

出版信息

Bioorg Med Chem Lett. 1998 Jun 16;8(12):1569-74. doi: 10.1016/s0960-894x(98)00265-0.

DOI:10.1016/s0960-894x(98)00265-0
PMID:9873392
Abstract

The synthesis and the pharmacological evaluation at metabotropic glutamate receptors of S-2-(4'-carboxy-cubyl)glycine (ACUDA, 9) are described. S-2-(4'-Carboxy-cubyl)glycine is a structurally novel group I selective antagonist for mGluR1 subtype.

摘要

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