苯甘氨酸衍生物作为Ⅲ型代谢型谷氨酸受体强效选择性拮抗剂的合成
Synthesis of phenylglycine derivatives as potent and selective antagonists of group III metabotropic glutamate receptors.
作者信息
Conway S J, Miller J C, Howson P A, Clark B P, Jane D E
机构信息
Department of Pharmacology, School of Medical Sciences, Bristol, UK.
出版信息
Bioorg Med Chem Lett. 2001 Mar 26;11(6):777-80. doi: 10.1016/s0960-894x(01)00052-x.
Abstract
The syntheses of a range of ring and alpha-substituted 4-phosphonophenylglycines are described. A brief discussion of the antagonist activities of compounds 4-10 on group I, II and III metabotropic glutamate (mGlu) receptors expressed in the neonatal rat spinal cord is included.
摘要
描述了一系列环取代和α-取代的4-膦酰基苯甘氨酸的合成方法。还简要讨论了化合物4-10对新生大鼠脊髓中表达的I、II和III组代谢型谷氨酸（mGlu）受体的拮抗活性。
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