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苯甘氨酸衍生物作为Ⅲ型代谢型谷氨酸受体强效选择性拮抗剂的合成

Synthesis of phenylglycine derivatives as potent and selective antagonists of group III metabotropic glutamate receptors.

作者信息

Conway S J, Miller J C, Howson P A, Clark B P, Jane D E

机构信息

Department of Pharmacology, School of Medical Sciences, Bristol, UK.

出版信息

Bioorg Med Chem Lett. 2001 Mar 26;11(6):777-80. doi: 10.1016/s0960-894x(01)00052-x.

DOI:10.1016/s0960-894x(01)00052-x
PMID:11277518
Abstract

The syntheses of a range of ring and alpha-substituted 4-phosphonophenylglycines are described. A brief discussion of the antagonist activities of compounds 4-10 on group I, II and III metabotropic glutamate (mGlu) receptors expressed in the neonatal rat spinal cord is included.

摘要

描述了一系列环取代和α-取代的4-膦酰基苯甘氨酸的合成方法。还简要讨论了化合物4-10对新生大鼠脊髓中表达的I、II和III组代谢型谷氨酸（mGlu）受体的拮抗活性。

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Synthesis of phenylglycine derivatives as potent and selective antagonists of group III metabotropic glutamate receptors.苯甘氨酸衍生物作为Ⅲ型代谢型谷氨酸受体强效选择性拮抗剂的合成
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Phenylglycine derivatives as antagonists of metabotropic glutamate receptors.作为代谢型谷氨酸受体拮抗剂的苯甘氨酸衍生物
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Phenylglycine derivatives as antagonists of group III metabotropic glutamate receptors expressed on neonatal rat primary afferent terminals.
苯甘氨酸衍生物作为新生大鼠初级传入神经末梢上表达的III型代谢型谷氨酸受体的拮抗剂。
Br J Pharmacol. 2003 Aug;139(8):1523-31. doi: 10.1038/sj.bjp.0705377.