4-乙基-2-氧代-2H-苯并吡喃-7-基的羧糖苷作为不可水解的口服活性静脉抗血栓形成剂。
Carbaxylosides of 4-ethyl-2-oxo-2H-benzopyran-7-yl as non-hydrolyzable, orally active venous antithrombotic agents.
作者信息
Jeanneret V, Vogel P, Renaut P, Millet J, Theveniaux J, Barberousse V
机构信息
Institut de chimie organique de l'Université de Lausanne, BCH, Lausanne-Dorigny, Switzerland.
出版信息
Bioorg Med Chem Lett. 1998 Jul 7;8(13):1687-8. doi: 10.1016/s0960-894x(98)00283-2.
A (-)-conduritol F derivative was condensed with 4-ethyl-7-hydroxy-2H-1-benzopyran-2-one and converted into (+)-4-ethyl-7-[(1'R,2'S,3'S,4'R)-2',3',4'- trihydroxycyclohexyloxy]-2H-1-benzopyran-2-one ((+)-2). Enantiomer (-)-2 was obtained from a (+)-conduritol F derivative. The carbaxyloside (-)-2 with the L-xylose configuration was more active than (+)-2 in the Wessler's model.
一种（-）-羟基环已六醇F衍生物与4-乙基-7-羟基-2H-1-苯并吡喃-2-酮缩合，然后转化为（+）-4-乙基-7-[(1'R,2'S,3'S,4'R)-2',3',4'-三羟基环己基氧基]-2H-1-苯并吡喃-2-酮（（+）-2）。对映体（-）-2由（+）-羟基环已六醇F衍生物制得。具有L-木糖构型的羧糖苷（-）-2在韦氏模型中比（+）-2更具活性。
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