Synthesis of a high-mannose-type glycopeptide analog containing a glucose-asparagine linkage.
作者信息
Deras I L, Takegawa K, Kondo A, Kato I, Lee Y C
机构信息
Biology Department, Johns Hopkins University, Baltimore, MD 21218, USA.
出版信息
Bioorg Med Chem Lett. 1998 Jul 7;8(13):1763-6. doi: 10.1016/s0960-894x(98)00306-0.
PMID:9873430
Abstract
The title compound was prepared by enzymatic transfer of oligosaccharide to a synthetic pentapeptide containing the Glc-Asn linkage. The compound was not hydrolyzed by glycoamidases from plant and bacterial sources, but it inhibited both enzymes in the micromolar range. Its activity is compared to other potential inhibitors.
摘要
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