Discovery of a novel benzyloxyisoquinoline derivative with potent anti-Helicobacter pylori activity.
作者信息
Yoshida Y, Barrett D, Azami H, Morinaga C, Matsumoto Y, Takasugi H
机构信息
Medicinal Chemistry Research Laboratories, Fujisawa Pharmaceutical Co. Ltd., Osaka, Japan.
出版信息
Bioorg Med Chem Lett. 1998 Jul 21;8(14):1897-902. doi: 10.1016/s0960-894x(98)00335-7.
PMID:9873455
Abstract
The synthesis and in vitro optimization of the anti-Helicobacter pylori activity of a novel series of benzyloxyisoquinoline derivatives discovered by a random screening process, are described. FR180102 (7f), having a 3-acetamido-2,6-dichlorobenzyl moiety, was found to have extremely potent activity against H. pylori and no effect against a series of common Gram-positive and Gram-negative bacteria.
摘要
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