Kogen H, Tago K, Arai M, Minami E, Masuda K, Akiyama T
Exploratory Chemistry Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
Bioorg Med Chem Lett. 1999 May 17;9(10):1347-50. doi: 10.1016/s0960-894x(99)00203-6.
Practical and highly stereoselective synthesis of diterpene alcohol, plaunotol (1) and its thiourea derivatives 2a, 3a and 4a, via Z-selective Wittig reaction between alpha-acetal ketone 5 and phosphonium salt 6 and their antibacterial activity against Helicobacter pylori are described.
通过α-缩醛酮5与鏻盐6之间的Z-选择性维蒂希反应，实现了二萜醇普劳诺托（1）及其硫脲衍生物2a、3a和4a的实用且高度立体选择性合成，并描述了它们对幽门螺杆菌的抗菌活性。
