普劳诺托及其硫脲衍生物作为抗幽门螺杆菌强效抗菌剂的高度立体选择性合成。

A highly stereoselective synthesis of plaunotol and its thiourea derivatives as potent antibacterial agents against Helicobacter pylori.

作者信息

Kogen H, Tago K, Arai M, Minami E, Masuda K, Akiyama T

机构信息

Exploratory Chemistry Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.

出版信息

Bioorg Med Chem Lett. 1999 May 17;9(10):1347-50. doi: 10.1016/s0960-894x(99)00203-6.

DOI:10.1016/s0960-894x(99)00203-6

PMID:10360733

Abstract

Practical and highly stereoselective synthesis of diterpene alcohol, plaunotol (1) and its thiourea derivatives 2a, 3a and 4a, via Z-selective Wittig reaction between alpha-acetal ketone 5 and phosphonium salt 6 and their antibacterial activity against Helicobacter pylori are described.

摘要

通过α-缩醛酮5与鏻盐6之间的Z-选择性维蒂希反应，实现了二萜醇普劳诺托（1）及其硫脲衍生物2a、3a和4a的实用且高度立体选择性合成，并描述了它们对幽门螺杆菌的抗菌活性。