布氏锥虫UDP-半乳糖：GPI锚定侧链α-半乳糖基转移酶的一种合成受体底物。
A synthetic acceptor substrate for Trypanosoma brucei UDP-Gal: GPI anchor side-chain alpha-galactosyltransferases.
作者信息
Brown J R, Smith T K, Ferguson M A, Field R A
机构信息
School of Chemistry, University of St Andrews, UK.
出版信息
Bioorg Med Chem Lett. 1998 Aug 4;8(15):2051-4. doi: 10.1016/s0960-894x(98)00359-x.
PMID:9873484
Abstract
A synthetic analogue of a trisaccharide fragment of the Trypanosoma brucei Variant Surface Glycoprotein (VSG) GlycosylPhosphatidyInositiol (GPI) anchor, Gal-alpha-1,3(Man-alpha-1,6)-Man-alpha-O-octyl (1), serves as a substrate for two T. brucei alpha-galactosyltransferases. The principle tetrasaccharide product derived from (1) contains a Gal-alpha-1,2-Gal linkage.
摘要
布氏锥虫可变表面糖蛋白（VSG）糖基磷脂酰肌醇（GPI）锚定的三糖片段的合成类似物，Gal-α-1,3(Man-α-1,6)-Man-α-O-辛基（1），作为两种布氏锥虫α-半乳糖基转移酶的底物。由（1）衍生的主要四糖产物含有Gal-α-1,2-Gal连接。
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