The asymmetric synthesis and in vitro characterization of succinyl mercaptoalcohol and mercaptoketone inhibitors of matrix metalloproteinases.

Suppr

超能文献

作者信息

Levin J I, DiJoseph J F, Killar L M, Sharr M A, Skotnicki J S, Patel D V, Xiao X Y, Shi L, Navre M, Campbell D A

机构信息

Wyeth-Ayerst Research, Pearl River, New York 10965, USA.

出版信息

Bioorg Med Chem Lett. 1998 May 19;8(10):1163-8. doi: 10.1016/s0960-894x(98)00186-3.

DOI:10.1016/s0960-894x(98)00186-3

PMID:9871728

Abstract

A series of succinyl based mercaptoketones and diastereomeric mercaptoalcohols were prepared and evaluated in vitro as inhibitors of the matrix metalloproteinases collagenase-1 (MMP-1), stromelysin (MMP-3), and gelatinase-B (MMP-9).

摘要

相似文献

The asymmetric synthesis and in vitro characterization of succinyl mercaptoalcohol and mercaptoketone inhibitors of matrix metalloproteinases.

Bioorg Med Chem Lett. 1998 May 19;8(10):1163-8. doi: 10.1016/s0960-894x(98)00186-3.

Malonyl alpha-mercaptoketones and alpha-mercaptoalcohols, a new class of matrix metalloproteinase inhibitors.丙二酰α-巯基酮和α-巯基醇，一类新型基质金属蛋白酶抑制剂。

Bioorg Med Chem Lett. 1998 May 19;8(10):1157-62. doi: 10.1016/s0960-894x(98)00185-1.

Design and synthesis of conformationally-constrained MMP inhibitors.

Bioorg Med Chem Lett. 1998 Aug 18;8(16):2077-80. doi: 10.1016/s0960-894x(98)00370-9.

The design, synthesis, and structure-activity relationships of a series of macrocyclic MMP inhibitors.

Bioorg Med Chem Lett. 1998 Aug 18;8(16):2087-92. doi: 10.1016/s0960-894x(98)00396-5.

Difluoroketones as inhibitors of matrix metalloprotease-13.二氟酮作为基质金属蛋白酶-13的抑制剂

Bioorg Med Chem Lett. 2000 Jul 17;10(14):1581-4. doi: 10.1016/s0960-894x(00)00287-0.

Structure-based design and synthesis of a series of hydroxamic acids with a quaternary-hydroxy group in P1 as inhibitors of matrix metalloproteinases.基于结构设计并合成一系列在P1位带有季羟基的异羟肟酸作为基质金属蛋白酶抑制剂。

Bioorg Med Chem Lett. 1998 Apr 7;8(7):837-42. doi: 10.1016/s0960-894x(98)00125-5.

Aryl ketones as novel replacements for the C-terminal amide bond of succinyl hydroxamate MMP inhibitors.

Bioorg Med Chem Lett. 1998 Nov 17;8(22):3251-6. doi: 10.1016/s0960-894x(98)00597-6.

Design and synthesis of phosphinamide-based hydroxamic acids as inhibitors of matrix metalloproteinases.基于磷酰胺的异羟肟酸作为基质金属蛋白酶抑制剂的设计与合成

J Med Chem. 1999 Jan 14;42(1):87-94. doi: 10.1021/jm980142s.

Discovery of a novel series of selective MMP inhibitors: identification of the gamma-sulfone-thiols.

Bioorg Med Chem Lett. 1999 Apr 5;9(7):943-8. doi: 10.1016/s0960-894x(99)00116-x.

Novel thiol-based TACE inhibitors. Part 2: Rational design, synthesis, and SAR of thiol-containing aryl sulfones.新型基于硫醇的TACE抑制剂。第2部分：含硫醇芳基砜的合理设计、合成及构效关系

Bioorg Med Chem Lett. 2008 Jan 1;18(1):44-8. doi: 10.1016/j.bmcl.2007.11.014. Epub 2007 Nov 13.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验