Effects of phosphorothioate oligodeoxyribonucleotide and oligoribonucleotides on human complement and coagulation.
作者信息
Kandimalla E R, Shaw D R, Agrawal S
机构信息
Hybridon, Inc., Cambridge, MA 02139, USA.
出版信息
Bioorg Med Chem Lett. 1998 Aug 18;8(16):2103-8. doi: 10.1016/s0960-894x(98)00368-0.
PMID:9873494
Abstract
We have synthesized and studied the effects of phosphorothioate (PS) oligodeoxyribonucleotide (DNA) and oligoribonucleotides (RNA, 2'-O-methyl-RNA and 2'-5'-RNA) on complement activation and prolongation of activated partial thromboplastin time (aPTT) in vitro. These results suggest that a PS-DNA prolongs aPTT, and inhibits complement lysis more than do the PS-RNA analogs.
摘要
Zotero 插件