• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Identification of N2-(1-carboxymethyl)guanine (CMG) as a guanine advanced glycation end product.

作者信息

al-Abed Y, Schleicher E, Voelter W, Liebich H, Papoulis A, Bucala R

机构信息

Picower Institute for Medical Research, Manhasset, NY 11030, USA.

出版信息

Bioorg Med Chem Lett. 1998 Aug 18;8(16):2109-10. doi: 10.1016/s0960-894x(98)00398-9.

DOI:10.1016/s0960-894x(98)00398-9
PMID:9873495
Abstract

The reaction of D-glucose with 9-methylguanine produces N2-fructosyl-9-methylguanine, which undergoes oxidation to produce N2-(1-carboxymethyl)-9-methylguanine as a major adduct.

摘要

相似文献

1
Identification of N2-(1-carboxymethyl)guanine (CMG) as a guanine advanced glycation end product.
Bioorg Med Chem Lett. 1998 Aug 18;8(16):2109-10. doi: 10.1016/s0960-894x(98)00398-9.
2
DNA-glycation leads to depurination by the loss of N2-carboxyethylguanine in vitro.
Cell Mol Biol (Noisy-le-grand). 1998 Nov;44(7):1165-70.
3
Immunochemical detection of N2-[1-(1-carboxy)ethyl]guanosine, an advanced glycation end product formed by the reaction of DNA and reducing sugars or L-ascorbic acid in vitro.
Biochim Biophys Acta. 1998 Nov 27;1425(3):478-84. doi: 10.1016/s0304-4165(98)00101-9.
4
Assay of advanced glycation endproducts (AGEs): surveying AGEs by chromatographic assay with derivatization by 6-aminoquinolyl-N-hydroxysuccinimidyl-carbamate and application to Nepsilon-carboxymethyl-lysine- and Nepsilon-(1-carboxyethyl)lysine-modified albumin.晚期糖基化终末产物（AGEs）的测定：采用6-氨基喹啉-N-羟基琥珀酰亚胺基-氨基甲酸酯衍生化的色谱分析法检测AGEs，并应用于Nε-羧甲基赖氨酸和Nε-（1-羧乙基）赖氨酸修饰的白蛋白。
Biochem J. 2002 May 15;364(Pt 1):1-14. doi: 10.1042/bj3640001.
5
Identification of N2-(1-carboxyethyl)guanine (CEG) as a guanine advanced glycosylation end product.鉴定N2-(1-羧乙基)鸟嘌呤（CEG）为鸟嘌呤晚期糖基化终产物。
Biochemistry. 1995 Jan 17;34(2):648-55. doi: 10.1021/bi00002a032.
6
Diet-derived advanced glycation end products or lipofuscin disrupts proteostasis and reduces life span in Drosophila melanogaster.饮食来源的晚期糖基化终产物或脂褐质会破坏果蝇的蛋白质稳态并缩短其寿命。
Free Radic Biol Med. 2013 Dec;65:1155-1163. doi: 10.1016/j.freeradbiomed.2013.08.186. Epub 2013 Aug 30.
7
Identity and localization of advanced glycation end products on human beta2-microglobulin using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.利用基质辅助激光解吸/电离飞行时间质谱法对人β2-微球蛋白上晚期糖基化终产物进行鉴定和定位
Anal Biochem. 2003 Mar 15;314(2):322-5. doi: 10.1016/s0003-2697(02)00690-5.
8
Presence of dopa and amino acid hydroperoxides in proteins modified with advanced glycation end products (AGEs): amino acid oxidation products as a possible source of oxidative stress induced by AGE proteins.晚期糖基化终产物（AGEs）修饰的蛋白质中存在多巴和氨基酸氢过氧化物：氨基酸氧化产物可能是AGE蛋白诱导氧化应激的来源。
Biochem J. 1998 Feb 15;330 ( Pt 1)(Pt 1):233-9. doi: 10.1042/bj3300233.
9
N epsilon-(carboxymethyl)lysine is a dominant advanced glycation end product (AGE) antigen in tissue proteins.N-ε-（羧甲基）赖氨酸是组织蛋白中主要的晚期糖基化终末产物（AGE）抗原。
Biochemistry. 1995 Aug 29;34(34):10872-8. doi: 10.1021/bi00034a021.
10
Chromatographic assay of glycation adducts in human serum albumin glycated in vitro by derivatization with 6-aminoquinolyl-N-hydroxysuccinimidyl-carbamate and intrinsic fluorescence.通过用6-氨基喹啉-N-羟基琥珀酰亚胺基氨基甲酸酯衍生化和固有荧光对体外糖基化的人血清白蛋白中的糖基化加合物进行色谱分析。
Biochem J. 2002 May 15;364(Pt 1):15-24. doi: 10.1042/bj3640015.

引用本文的文献

1
Methylglyoxal and Its Adducts: Induction, Repair, and Association with Disease.甲基乙二醛及其加合物：诱导、修复及与疾病的关联。
Chem Res Toxicol. 2022 Oct 17;35(10):1720-1746. doi: 10.1021/acs.chemrestox.2c00160. Epub 2022 Oct 5.
2
Characterization of the deoxyguanosine-lysine cross-link of methylglyoxal.甲基乙二醛的脱氧鸟苷-赖氨酸交联的表征
Chem Res Toxicol. 2014 Jun 16;27(6):1019-29. doi: 10.1021/tx500068v. Epub 2014 May 15.
3
Molecular susceptibility to glycation and its implication in diabetes mellitus and related diseases.
分子对糖化的易感性及其在糖尿病及相关疾病中的意义。
Mol Cell Biochem. 2010 Nov;344(1-2):185-93. doi: 10.1007/s11010-010-0541-3. Epub 2010 Jul 31.