Wei Y, Yan Y, Pei D, Gong B
Department of Chemistry, Ohio State University, Columbus 43210, USA.
Bioorg Med Chem Lett. 1998 Sep 22;8(18):2419-22. doi: 10.1016/s0960-894x(98)00437-5.
A photolabile derivative (1) of the anticancer drug, 5-fluorodeoxyuridine (2), was designed and synthesized as a model prodrug. Photolysis of 1 with long-wavelength UV light rapidly released 2 in solution. While compound 1 alone is nontoxic to cells, the presence of both 1 and UV irradiation (lambda = 350 nm) resulted in potent inhibition of cell growth.
