Synthesis and antibacterial activity of novel 7-(3-substituted-3 or 4-trifluoromethyl-1-pyrrolidinyl)-8-methoxyfluoroquinolones.
作者信息
Fukui H, Shibata T, Naito T, Nakano J, Maejima T, Senda H, Iwatani W, Tatsumi Y, Suda M, Arika T
机构信息
Central Research Institute, Kaken Pharmaceutical Co., Ltd., Kyoto, Japan.
出版信息
Bioorg Med Chem Lett. 1998 Oct 20;8(20):2833-8. doi: 10.1016/s0960-894x(98)00514-9.
PMID:9873632
Abstract
The titled compounds were synthesized and evaluated for in vitro antibacterial activity. The (3R, 4S)-3-aminomethyl-4-trifluoromethyl derivative (S-34109) was confirmed to be optimal because of its superior activity against quinolone and methicillin-resistant Staphylococcus aureus and low side effect potential.
摘要
Zotero 插件