Morihira K, Nishimori T, Kusama H, Horiguchi Y, Kuwajima I, Tsuruo T
Department of Chemistry, Tokyo Institute of Technology, Japan.
Bioorg Med Chem Lett. 1998 Nov 3;8(21):2977-82. doi: 10.1016/S0960-894X(98)00540-X.
Artificial taxoids were synthesized and subjected to evaluation of their ability of multi-drug resistance reversing and antitumor activities. While the taxoid 4 could not increase cellular accumulation of vincristine in multi-drug resistant tumor cells, the C4-hydroxy analog 15 showed significant effect. However, these compounds showed weak activities on growth inhibition of cancer cells.
