Ostaszewski R, Wilczyńska E, Wolszczak M
Institute of Organic Chemistry, Polish Academy of Sciences, Warszawa.
Bioorg Med Chem Lett. 1998 Nov 3;8(21):2995-6. doi: 10.1016/S0960-894X(98)00533-2.
A new type of DNA intercalator based on anthracene 3 was synthesized. Preliminary binding studies show high affinity of this probe to CT-DNA. Higher binding constant of this compound (4.0 x 10(4) M-1) as compared with that known for 9-aminomethylanthracene, is caused presumably by enhanced electrostatic interaction.
